UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures
The 5-methylcytosine (5mC) modification regulates multiple Above Ground Product (Pumps) cellular processes and is faithfully maintained following DNA replication.In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5mC levels